Tyrone Chen

Tyrone Chen

PhD student at Monash University

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publications

A molecular classification of human mesenchymal stromal cells

Published in PeerJ, 2016

The Rohart MSC test is a simple in silico test that accurately discriminates MSC from fibroblasts, other adult stem/progenitor cell types or differentiated stromal cells.

Recommended citation: Florian Rohart, Elizabeth A. Mason, Nicholas Matigian, Rowland Mosbergen, Othmar Korn, Tyrone Chen, Suzanne Butcher, Jatin Patel, Kerry Atkinson, Kiarash Khosrotehrani, Nicholas M. Fisk, Kim-Anh Lê Cao, Christine A. Wells​, "A molecular classification of human mesenchymal stromal cells." PeerJ, 2016, 4:e1845. DOI: https://doi.org/10.7717/peerj.1845 https://doi.org/10.7717/peerj.1845

Mesenchymal Stromal Cells are Readily Recoverable from Lung Tissue, but not the Alveolar Space, in Healthy Humans

Published in Stem Cells, 2016

This investigation comprehensively characterizes and contrasts human lung derived mesenchymal stromal cells (MSCs) from tissue and bronchoalveolar lavage.

Recommended citation: Kenneth A Sinclair, Stephanie T Yerkovich, Tyrone Chen, Jonathan L McQualter, Peter M-A Hopkins, Christine A Wells, Daniel C Chambers, "Mesenchymal Stromal Cells are Readily Recoverable from Lung Tissue, but not the Alveolar Space, in Healthy Humans" Stem Cells, 2016, 34: 2548-2558. DOI: https://doi.org/10.1002/stem.2419 https://doi.org/10.1002/stem.2419

Stemformatics: visualize and download curated stem cell data

Published in Nucleic Acids Research, 2018

Stemformatics includes curated ‘collections’ of data relevant to cell reprogramming, as well as hematopoiesis and leukaemia.

Recommended citation: Jarny Choi, Chris M Pacheco, Rowland Mosbergen, Othmar Korn, Tyrone Chen, Isha Nagpal, Steve Englart, Paul W Angel, Christine A Wells, "Stemformatics: visualize and download curated stem cell data." Nucleic Acids Research, Volume 47, Issue D1, 08 January 2019, Pages D841–D846. DOI: https://doi.org/10.1093/nar/gky1064 https://doi.org/10.1093/nar/gky1064

Multipotent RAG1+ progenitors emerge directly from haemogenic endothelium in human pluripotent stem cell-derived haematopoietic organoids

Published in Nature Cell Biology, 2020

We provide evidence for a wave of human T-cell development that originates directly from haemogenic endothelium via a RAG1+ intermediate with multilineage potential.

Recommended citation: Ali Motazedian, Freya F. Bruveris, Santhosh V. Kumar, Jacqueline V. Schiesser, Tyrone Chen, Elizabeth S. Ng, Ann P. Chidgey, Christine A. Wells, Andrew G. Elefanty, Edouard G. Stanley, "Multipotent RAG1+ progenitors emerge directly from haemogenic endothelium in human pluripotent stem cell-derived haematopoietic organoids." Nat Cell Biol 22, 60–73 (2020). DOI: https://doi.org/10.1038/s41556-019-0445-8 https://rdcu.be/b440v

A simple, scalable approach to building a cross-platform transcriptome atlas

Published in bioRxiv, 2020

We demonstrate that it is possible to combine a large number of different profiling experiments summarised from dozens of laboratories and representing hundreds of donors, to create an integrated molecular map of human tissue.

Recommended citation: Paul W Angel, Nadia Rajab, Yidi Deng, Chris M Pacheco, Tyrone Chen, Kim-Anh Lê Cao, Jarny Choi, Christine A Wells, "A simple, scalable approach to building a cross-platform transcriptome atlas." bioRxiv, 2020.03.09.984468. DOI: https://doi.org/10.1101/2020.03.09.984468 https://doi.org/10.1101/2020.03.09.984468

Integrative computational epigenomics to build data-driven gene regulation hypotheses

Published in GigaScience, 2020

In this review, we perform a critical analysis of methods with the explicit aim of harmonizing data, as opposed to case-specific integration.

Recommended citation: Tyrone Chen, Sonika Tyagi, "Integrative computational epigenomics to build data-driven gene regulation hypotheses." GigaScience, Volume 9, Issue 6, June 2020, giaa064. DOI: https://doi.org/10.1093/gigascience/giaa064 http://dx.doi.org/10.1093/gigascience/giaa064

talks

teaching

Peer mentoring

Tutoring, Australian National University, Research School of Biology, 2011

2011